In vivo multiphoton microscopy imaging of melasma

Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess th...

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Bibliographic Details
Published in:Pigment cell and melanoma research 2018-12, Vol.32 (3), p.403-411
Main Authors: Lentsch, Griffin, Balu, Mihaela, Williams, Joshua, Lee, Sanghoon, Harris, Ronald M., König, Karsten, Ganesan, Anand, Tromberg, Bruce J., Nair, Nirmala, Santhanam, Uma, Misra, Manoj
Format: Article
Language:English
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Summary:Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in-vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. We imaged dermal melanophages in most dermal melasma lesions and occasionally in epidermal melasma. The melanin volume fraction values measured in epidermal melasma (14±4%) were significantly higher (p
ISSN:1755-1471
1755-148X
DOI:10.1111/pcmr.12756