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Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis
Long noncoding RNAs (lncRNAs) play an important role in lung adenocarcinoma (LUAD) metastasis. Here, we found that lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis in vitro and in vivo. Mechanistically, CAR10 induced e...
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| Published in: | Oncogene 2019-04, Vol.38 (16), p.3061-3076 |
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| Main Authors: | , , , , , , , , , , , |
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| container_end_page | 3076 |
| container_issue | 16 |
| container_start_page | 3061 |
| container_title | Oncogene |
| container_volume | 38 |
| creator | Ge, Xiaolu Li, Gui-yuan Jiang, Lin Jia, Liqing Zhang, Zhezhe Li, Xiaoling Wang, Ranran Zhou, Ming Zhou, Yanhong Zeng, Zhaoyang Xiang, Juanjuan Li, Zheng |
| description | Long noncoding RNAs (lncRNAs) play an important role in lung adenocarcinoma (LUAD) metastasis. Here, we found that lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis in vitro and in vivo. Mechanistically, CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of
SNAI1
and
SNAI2
. CAR10 overexpression was positively correlated with a poor prognosis in LUAD patients, whereas overexpression of both CAR10 and
SNAI
was correlated with even worse clinical outcomes. In conclusion, the CAR10/miR-30/203/
SNAI
axis is a novel and potential therapeutic target for LUAD. |
| doi_str_mv | 10.1038/s41388-018-0645-x |
| format | article |
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SNAI1
and
SNAI2
. CAR10 overexpression was positively correlated with a poor prognosis in LUAD patients, whereas overexpression of both CAR10 and
SNAI
was correlated with even worse clinical outcomes. In conclusion, the CAR10/miR-30/203/
SNAI
axis is a novel and potential therapeutic target for LUAD.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/s41388-018-0645-x</identifier><identifier>PMID: 30617305</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/109 ; 13/44 ; 13/51 ; 13/89 ; 14/1 ; 14/19 ; 14/34 ; 14/35 ; 14/5 ; 14/63 ; 38/1 ; 38/22 ; 38/23 ; 38/39 ; 38/44 ; 38/47 ; 38/61 ; 38/89 ; 42/41 ; 42/44 ; 42/89 ; 59/5 ; 631/337/384 ; 631/67/1612/1350 ; 631/67/322 ; 64/60 ; 82/1 ; A549 Cells ; Adenocarcinoma ; Adenocarcinoma of Lung - genetics ; Animals ; Antisense RNA ; Apoptosis ; Cancer metastasis ; Cell Biology ; Cell Line ; Cell Line, Tumor ; Chromatin ; Chromatin - genetics ; Crizotinib ; Development and progression ; Epithelial-Mesenchymal Transition - genetics ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic - genetics ; Genetic aspects ; HEK293 Cells ; HeLa Cells ; Hep G2 Cells ; Human Genetics ; Humans ; Internal Medicine ; Lung cancer ; Lung Neoplasms - genetics ; MCF-7 Cells ; Medical schools ; Medicine ; Medicine & Public Health ; Melanoma, Experimental - genetics ; Mesenchyme ; Metastases ; Metastasis ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs - genetics ; Novels ; Oncology ; Prognosis ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; Snail Family Transcription Factors - genetics ; Snail protein ; Stem cells ; Therapeutic applications ; Tumors ; Up-Regulation - genetics</subject><ispartof>Oncogene, 2019-04, Vol.38 (16), p.3061-3076</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2019 Nature Publishing Group</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-faf8780615fe1182585d8e83cdc697e5c68ecdb4b499df9f2b264dddb8319e913</citedby><cites>FETCH-LOGICAL-c537t-faf8780615fe1182585d8e83cdc697e5c68ecdb4b499df9f2b264dddb8319e913</cites><orcidid>0000-0001-8712-8952</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30617305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ge, Xiaolu</creatorcontrib><creatorcontrib>Li, Gui-yuan</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Jia, Liqing</creatorcontrib><creatorcontrib>Zhang, Zhezhe</creatorcontrib><creatorcontrib>Li, Xiaoling</creatorcontrib><creatorcontrib>Wang, Ranran</creatorcontrib><creatorcontrib>Zhou, Ming</creatorcontrib><creatorcontrib>Zhou, Yanhong</creatorcontrib><creatorcontrib>Zeng, Zhaoyang</creatorcontrib><creatorcontrib>Xiang, Juanjuan</creatorcontrib><creatorcontrib>Li, Zheng</creatorcontrib><title>Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Long noncoding RNAs (lncRNAs) play an important role in lung adenocarcinoma (LUAD) metastasis. Here, we found that lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis in vitro and in vivo. Mechanistically, CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of
SNAI1
and
SNAI2
. CAR10 overexpression was positively correlated with a poor prognosis in LUAD patients, whereas overexpression of both CAR10 and
SNAI
was correlated with even worse clinical outcomes. In conclusion, the CAR10/miR-30/203/
SNAI
axis is a novel and potential therapeutic target for LUAD.</description><subject>13/1</subject><subject>13/109</subject><subject>13/44</subject><subject>13/51</subject><subject>13/89</subject><subject>14/1</subject><subject>14/19</subject><subject>14/34</subject><subject>14/35</subject><subject>14/5</subject><subject>14/63</subject><subject>38/1</subject><subject>38/22</subject><subject>38/23</subject><subject>38/39</subject><subject>38/44</subject><subject>38/47</subject><subject>38/61</subject><subject>38/89</subject><subject>42/41</subject><subject>42/44</subject><subject>42/89</subject><subject>59/5</subject><subject>631/337/384</subject><subject>631/67/1612/1350</subject><subject>631/67/322</subject><subject>64/60</subject><subject>82/1</subject><subject>A549 Cells</subject><subject>Adenocarcinoma</subject><subject>Adenocarcinoma of Lung - genetics</subject><subject>Animals</subject><subject>Antisense RNA</subject><subject>Apoptosis</subject><subject>Cancer metastasis</subject><subject>Cell Biology</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Chromatin</subject><subject>Chromatin - genetics</subject><subject>Crizotinib</subject><subject>Development and progression</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Genetic aspects</subject><subject>HEK293 Cells</subject><subject>HeLa Cells</subject><subject>Hep G2 Cells</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>MCF-7 Cells</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma, Experimental - genetics</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>MicroRNAs - genetics</subject><subject>Novels</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - 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Here, we found that lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis in vitro and in vivo. Mechanistically, CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of
SNAI1
and
SNAI2
. CAR10 overexpression was positively correlated with a poor prognosis in LUAD patients, whereas overexpression of both CAR10 and
SNAI
was correlated with even worse clinical outcomes. In conclusion, the CAR10/miR-30/203/
SNAI
axis is a novel and potential therapeutic target for LUAD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30617305</pmid><doi>10.1038/s41388-018-0645-x</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-8712-8952</orcidid><oa>free_for_read</oa></addata></record> |
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| source | LexisNexis - News & Business; Springer Link |
| subjects | 13/1 13/109 13/44 13/51 13/89 14/1 14/19 14/34 14/35 14/5 14/63 38/1 38/22 38/23 38/39 38/44 38/47 38/61 38/89 42/41 42/44 42/89 59/5 631/337/384 631/67/1612/1350 631/67/322 64/60 82/1 A549 Cells Adenocarcinoma Adenocarcinoma of Lung - genetics Animals Antisense RNA Apoptosis Cancer metastasis Cell Biology Cell Line Cell Line, Tumor Chromatin Chromatin - genetics Crizotinib Development and progression Epithelial-Mesenchymal Transition - genetics Female Gene expression Gene Expression Regulation, Neoplastic - genetics Genetic aspects HEK293 Cells HeLa Cells Hep G2 Cells Human Genetics Humans Internal Medicine Lung cancer Lung Neoplasms - genetics MCF-7 Cells Medical schools Medicine Medicine & Public Health Melanoma, Experimental - genetics Mesenchyme Metastases Metastasis Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics Novels Oncology Prognosis Ribonucleic acid RNA RNA, Long Noncoding - genetics Snail Family Transcription Factors - genetics Snail protein Stem cells Therapeutic applications Tumors Up-Regulation - genetics |
| title | Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis |
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