Impacts of AURKA Genetic Polymorphism on Urothelial Cell Carcinoma Development

Urothelial cell carcinoma (UCC) is the most common primary malignancy of the urinary system and the second-most common type of renal cell carcinoma. Aurora kinase A (AURKA), a serine/threonine kinase, has a critical role in centrosome duplication, spindle assembly checkpoint, and cytokinesis. Here,...

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Published in:Journal of Cancer 2019-01, Vol.10 (6), p.1370-1374
Main Authors: Huang, Chia-Hung, Chen, Chih-Jung, Chen, Pei-Ni, Wang, Shian-Shiang, Chou, Ying-Erh, Hung, Sheng-Chun, Yang, Shun-Fa
Format: Article
Language:English
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Summary:Urothelial cell carcinoma (UCC) is the most common primary malignancy of the urinary system and the second-most common type of renal cell carcinoma. Aurora kinase A (AURKA), a serine/threonine kinase, has a critical role in centrosome duplication, spindle assembly checkpoint, and cytokinesis. Here, we determined the correlation between UCC susceptibility and polymorphisms. We used real-time polymerase chain reaction to compare the genotype distributions and allelic frequencies of four single-nucleotide polymorphisms (SNPs) of , namely rs1047972, rs2273535, rs2064863, and rs6024836, between 431 UCC cases and 862 healthy controls. Logistic regression models demonstrated that the G allele of rs2064863, a genetic polymorphism of AURKA, exhibited a significant protective effect against UCC among the 862 nonsmokers. Moreover, patients with rs2064863 G allele exhibited a slightly lower risk of lymph node metastasis and those with rs6024836 G allele exhibited a lower risk of distant metastases. Our study suggested that several variants of SNPs rs2064863 and rs6024836 may serve as critical predictors for the clinical status of UCC.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.30014