The impact of revascularization on myocardial blood flow as assessed by positron emission tomography

Purpose Revascularization aims to improve myocardial perfusion. However, changes in regional artery-specific quantitative perfusion after revascularization have not been systematically investigated. It is unclear whether artery-specific thresholds for coronary flow capacity (CFC) and/or relative per...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2019-06, Vol.46 (6), p.1226-1239
Main Authors: Bober, Robert M., Milani, Richard V., Oktay, Ahmet A., Javed, Fahad, Polin, Nichole M., Morin, Daniel P.
Format: Article
Language:English
Subjects:
Abnormalities
Blood flow
Cardiology
Emission analysis
Heart
Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Original
Original Article
Orthopedics
Patients
Perfusion
Positron emission
Positron emission tomography
Radiology
Stenosis
Thresholds
Tomography
Veins & arteries
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Summary:Purpose Revascularization aims to improve myocardial perfusion. However, changes in regional artery-specific quantitative perfusion after revascularization have not been systematically investigated. It is unclear whether artery-specific thresholds for coronary flow capacity (CFC) and/or relative perfusion predict improved stress perfusion after revascularization. We sought to determine the impact of revascularization based on predefined, artery-specific, severity size thresholds for CFC and/or relative perfusion defects. Methods Fifty patients underwent PET imaging before revascularization and then prospectively within 90 days after revascularization. Changes in regional myocardial blood flow (MBF) were stratified based on baseline perfusion abnormalities, baseline reduced CFC, and whether revascularization was performed in that region. Results Following angiographic stenosis-directed revascularization, in regions with relative perfusion abnormalities and decreased CFC, stress MBF (sMBF) increased by 0.51 cm 3 /min/g (59%) from baseline ( p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-019-04278-8