Organoids of liver diseases: From bench to bedside

Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2019-04, Vol.25 (16), p.1913-1927
Main Authors: Wu, Li-Jun, Chen, Zi-Yan, Wang, Yi, Zhao, Jun-Gang, Xie, Xiao-Zai, Chen, Gang
Format: Article
Language:English
Subjects:
Animals
Cell Culture Techniques - methods
Disease Models, Animal
Drug Evaluation, Preclinical - methods
Humans
Liver - cytology
Liver - pathology
Liver Diseases - pathology
Liver Diseases - therapy
Organoids - drug effects
Regenerative Medicine - methods
Review
Translational Medical Research - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological specimens, . However, these methods cannot fully reveal the pathogenic mechanism and therapeutic characteristics of individualized liver diseases. Recent advances in three-dimensional cell culture technology (organoid culture techniques) include pluripotent stem cells and adult stem cells that are cultured to form self-organizing properties, making it possible to achieve individualized liver disease research. This review provides a comprehensive overview of the development of liver organoids, the existing and potential applications of liver regenerative medicine, the pathogenesis of liver disease heterogeneity, and drug screening.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v25.i16.1913