Pre-eclampsia and risk of later kidney disease: nationwide cohort study

ABSTRACTObjectiveTo investigate associations between pre-eclampsia and later risk of kidney disease.DesignNationwide register based cohort study.SettingDenmark.PopulationAll women with at least one pregnancy lasting at least 20 weeks between 1978 and 2015.Main outcome measureHazard ratios comparing...

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Bibliographic Details
Published in:BMJ (Online) 2019-04, Vol.365, p.l1516-l1516
Main Authors: Kristensen, Jonas H, Basit, Saima, Wohlfahrt, Jan, Damholt, Mette Brimnes, Boyd, Heather A
Format: Article
Language:English
Subjects:
Adult
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - epidemiology
Cohort analysis
Denmark - epidemiology
Diabetes
Female
Gestational Age
Humans
Hypertension
Hypertension - complications
Hypertension - epidemiology
Hypertension, Renal - complications
Hypertension, Renal - epidemiology
Kidney diseases
Kidney Diseases - diagnosis
Kidney Diseases - epidemiology
Kidney Diseases - etiology
Medical research
Monitoring, Physiologic - standards
Population studies
Postpartum Period
Pre-eclampsia
Pre-Eclampsia - diagnosis
Pre-Eclampsia - epidemiology
Preeclampsia
Pregnancy
Public health
Risk Factors
Womens health
Young Adult
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Summary:ABSTRACTObjectiveTo investigate associations between pre-eclampsia and later risk of kidney disease.DesignNationwide register based cohort study.SettingDenmark.PopulationAll women with at least one pregnancy lasting at least 20 weeks between 1978 and 2015.Main outcome measureHazard ratios comparing rates of kidney disease between women with and without a history of pre-eclampsia, stratified by gestational age at delivery and estimated using Cox regression.ResultsThe cohort consisted of 1 072 330 women followed for 19 994 470 person years (average 18.6 years/woman). Compared with women with no previous pre-eclampsia, those with a history of pre-eclampsia were more likely to develop chronic renal conditions: hazard ratio 3.93 (95% confidence interval 2.90 to 5.33, for early preterm pre-eclampsia (delivery
ISSN:0959-8138
1756-1833
DOI:10.1136/bmj.l1516