Advances in chronic cerebral circulation insufficiency

Summary Chronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long‐term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vasc...

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Bibliographic Details
Published in:CNS neuroscience & therapeutics 2018-01, Vol.24 (1), p.5-17
Main Authors: Zhou, Da, Meng, Ran, Li, Si‐Jie, Ya, Jing‐Yuan, Ding, Jia‐Yue, Shang, Shu‐Ling, Ding, Yu‐Chuan, Ji, Xun‐Ming
Format: Article
Language:English
Subjects:
Animals
Blood flow
Brain Ischemia - complications
Brain Ischemia - diagnostic imaging
Brain Ischemia - epidemiology
Cerebral blood flow
Cerebrovascular Circulation - physiology
chronic cerebral circulation insufficiency
clinical manifestation
Cognitive ability
Dementia disorders
Dementia, Vascular - diagnostic imaging
Dementia, Vascular - epidemiology
Dementia, Vascular - etiology
diagnosis
Etiology
Experimental research
Humans
Ischemia
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - diagnostic imaging
Ischemic Attack, Transient - epidemiology
Pathophysiology
Review
Stroke
Stroke - diagnostic imaging
Stroke - etiology
treatment
Vascular dementia
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Summary:Summary Chronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long‐term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, resulting in disability and mortality worldwide. This review summarizes the features and recent progress of CCCI, mainly focusing on epidemiology, experimental research, pathophysiology, etiology, clinical manifestations, imaging presentation, diagnosis, and potential therapeutic regimens. Some research directions are briefly discussed as well.
ISSN:1755-5930
1755-5949
DOI:10.1111/cns.12780