Metabolically Active, Fully Hydrolysable Polymersomes

The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile). They self‐assemble into biodegrada...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-03, Vol.58 (14), p.4581-4586
Main Authors: Zhu, Yunqing, Poma, Alessandro, Rizzello, Loris, Gouveia, Virginia M., Ruiz‐Perez, Lorena, Battaglia, Giuseppe, Williams, Charlotte K.
Format: Article
Language:English
Subjects:
Aliphatic compounds
Apoptosis
Apoptosis - drug effects
Biodegradability
Biodegradation
Cell Line, Tumor
Cell proliferation
Cell Proliferation - drug effects
Cell Survival - drug effects
cells
Chemical synthesis
Communication
Communications
Degradation products
drug discovery
Fibroblasts - chemistry
Fibroblasts - metabolism
Humans
Hydrolysis
Macrophages
Macrophages - drug effects
Macrophages - metabolism
Molecular Structure
Optical Imaging
Particle Size
Polycaprolactone
Polyester resins
Polyesters
Polyesters - chemistry
Polyesters - metabolism
Polyesters - pharmacology
polymers
ring opening
self-assembly
Succinic acid
Surface Properties
Surface-Active Agents - chemistry
Surface-Active Agents - metabolism
Surface-Active Agents - pharmacology
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Summary:The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile). They self‐assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent. Class act: The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. They self‐assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201814320