Regenerating Eye Tissues to Preserve and Restore Vision

Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D stru...

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Bibliographic Details
Published in:Cell stem cell 2018-06, Vol.22 (6), p.834-849
Main Authors: Stern, Jeffrey H., Tian, Yangzi, Funderburgh, James, Pellegrini, Graziella, Zhang, Kang, Goldberg, Jeffrey L., Ali, Robin R., Young, Michael, Xie, Yubing, Temple, Sally
Format: Article
Language:English
Subjects:
Animals
cornea
Cornea - cytology
eye
Eye Diseases - surgery
Eye Diseases - therapy
Humans
lens
limbal
ocular
ophthalmology
optic nerve
photoreceptors
Regeneration
regenerative medicine
retina
Retina - cytology
retinal ganglion cells
retinal pigment epithelium
stem cells
Stem Cells - cytology
trabecular meshwork
Vision, Ocular
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Summary:Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D structures combining cells and natural or artificial substrates, are in the pipeline. Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing. While recognizing the challenges, we look forward to a deep portfolio of sight-restoring, stem cell-based medicine. [Display omitted] Stern et al. review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2018.05.013