Effects of Burdock tea on recurrence of colonic diverticulitis and diverticular bleeding: An open-labelled randomized clinical trial

Colonic diverticular bleeding (CDB) and acute colonic diverticulitis (ACD) show high recurrence rates. The establishment of optimal strategies that prevent the recurrence of CDB and ACD is a major concern among gastroenterologists. This study aimed to assess the efficacy of burdock tea for preventin...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.6793-6793, Article 6793
Main Authors: Mizuki, Akira, Tatemichi, Masayuki, Nakazawa, Atsushi, Tsukada, Nobuhiro, Nagata, Hiroshi, Kinoshita, Yoshikazu
Format: Article
Language:English
Subjects:
692/4020/1503/1581/1392
692/4020/1503/197/2748
Adult
Aged
Aged, 80 and over
Arctium
Bleeding
Clinical trials
Diverticular Diseases - drug therapy
Diverticular Diseases - pathology
Diverticulitis, Colonic - drug therapy
Diverticulitis, Colonic - pathology
Female
Follow-Up Studies
Gastrointestinal Hemorrhage - drug therapy
Gastrointestinal Hemorrhage - pathology
Humanities and Social Sciences
Humans
Male
Middle Aged
multidisciplinary
Prognosis
Prospective Studies
Recurrence
Science
Science (multidisciplinary)
Survival Rate
Tea
Young Adult
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Summary:Colonic diverticular bleeding (CDB) and acute colonic diverticulitis (ACD) show high recurrence rates. The establishment of optimal strategies that prevent the recurrence of CDB and ACD is a major concern among gastroenterologists. This study aimed to assess the efficacy of burdock tea for preventing CDB and ACD recurrences. Newly diagnosed patients with CDB (n = 91) or ACD (n = 70) were randomly assigned into two groups. The experimental group received 1.5 g of burdock tea three times a day, whereas the control group did not receive any treatment. The median (interquartile range) of observation for recurrence of CDB or ACD was 22.0 (14.1) months and 30.3 (18.6), respectively. The burdock tea treatment showed significant preventive effects on recurrence of ACD. A lower ACD recurrence rate (5/47 [10.6%] vs. 14/44 [31.8%]) and longer recurrence-free duration was observed in the burdock tea group (59.3 months [95% CI: 54.0–64.7] vs. 45.1 months [95% CI: 37.1–53.0] by the Kaplan-Meier analysis; p = 0.012 by log rank test) than in the control group, although there was no significant preventive effects on the CDB recurrence. This randomized clinical trial demonstrated that daily intake of burdock tea could be an effective strategy for prevention of ACD recurrence, but not for CDB recurrence.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-43236-0