Immunoprofiling of Colitis-associated and Sporadic Colorectal Cancer and its Clinical Significance

Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple immune markers, is a novel method for examining the tumor immune environment. We compared the...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.6833-6833, Article 6833
Main Authors: Soh, Jae Seung, Jo, Su In, Lee, Hyejin, Do, Eun-ju, Hwang, Sung Wook, Park, Sang Hyoung, Ye, Byong Duk, Byeon, Jeong-Sik, Yang, Suk-Kyun, Kim, Ji Hun, Yang, Dong-Hoon, Kim, Sang-Yeob, Myung, Seung-Jae
Format: Article
Language:English
Subjects:
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Adult
Aged
Apoptosis
CD3 antigen
CD3 Complex - metabolism
CD8 antigen
CD8-Positive T-Lymphocytes - metabolism
Clinical significance
Colitis
Colitis - immunology
Colitis - mortality
Colitis - pathology
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - immunology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Forkhead Transcription Factors - metabolism
Foxp3 protein
Humanities and Social Sciences
Humans
Immunohistochemistry
Immunotherapy
Inflammatory bowel disease
Invasiveness
Male
Medical prognosis
Middle Aged
multidisciplinary
Neoplasms - immunology
Neoplasms - mortality
Neoplasms - pathology
PD-L1 protein
Phenotypes
Prognosis
Programmed Cell Death 1 Receptor - metabolism
Science
Science (multidisciplinary)
Surface markers
Tumors
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Summary:Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple immune markers, is a novel method for examining the tumor immune environment. We compared the expression levels of various surface markers in immune cells between colitis-associated cancer (CAC) and sporadic colorectal cancer (CRC) and evaluated the clinical usefulness of immunoprofiling in CRC. Tumor specimens from 24 CAC patients and 48 sporadic CRC patients, matched by age, sex, and tumor location to CAC, were included in the analysis. The expression levels of CD3, CD8, Foxp3, and programmed death-ligand 1 (PD-L1) in immune cells at the invasive margins of tumor tissues were evaluated by quantitative multispectral imaging. The CAC group had significantly less levels of cells expressing CD3, CD8, Foxp3, or PD-L1 (all, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-42986-1