Evaluation of the extent of neoplastic infiltration in small intestinal tumours in dogs

• Published in: Veterinary medicine and science 2019-05, Vol.5 (2), p.189-198
• Main Authors: Morrice, Michael, Polton, Gerry, Beck, Sam
• Format: Article
• Language: English
• Subjects: Animals; Antigens; Automation; canine; Carcinoma; Carcinoma - surgery; Carcinoma - veterinary; Chemotherapy; Dog Diseases - surgery; Dogs; Female; Histology; Intestinal Neoplasms - surgery; Intestinal Neoplasms - veterinary; Intestine; Intestine, Small - surgery; Lymphatic system; Lymphoma; Male; margin; Margins of Excision; Mesentery; Metastases; Metastasis; Oncology; Original; Pathology; Sarcoma - surgery; Sarcoma - veterinary; Surgery; Tumors; tumour
• ISSN: 2053-1095; 2053-1095
• DOI: 10.1002/vms3.147

There is currently a lack of evidence‐based guidance when determining surgical margins for small intestinal tumours in dogs. The purpose of this study is to help the surgeon make informed clinical decisions about margins when confronted with a small intestinal mass. Twenty‐seven canine small intestinal tumours were histologically diagnosed and then had further histological assessment at every centimeter from the edge of the palpable tumour to the surgical margin in oral, aboral and mesenteric directions. In all 10 carcinomas a 3 cm tissue margin in oral, aboral and mesenteric directions would have resulted in complete tumour resection. In all 11 sarcomas a 2 cm tissue margin in oral, aboral and mesenteric directions would have resulted in complete tumour resection. Five of the six intestinal lymphomas would have required tissue margins of 4 cm or more for complete resection. Of the 21 non‐lymphoma tumours assessed in this study, complete resection was achieved in all 21 (100%) with tissue margins at 3 cm from the palpable edge of the mass, 20 (95%) with tissue margins at 2 cm from the palpable edge of the mass, and 16 (76%) with tissue margins at 1 cm from the palpable edge of the mass in oral and aboral directions. All non‐lymphoma canine small intestinal masses will be completely resected when tissue margins are 3 cm from the palpable edge of the mass in oral and aboral directions after fixation in formalin. This research is assessing neoplastic infiltration of intestinal tumours away from the discrete mass. Twenty‐seven canine intestinal tumours have been assessed with the result that the majority of non‐lymphoma canine intestinal tumours will be completely removed with 3 cm surgical margins.