Repair Scaffolding Reaches New Heights at Blocked Replication Forks

In this issue of Molecular Cell, Ohouo et al. (2010) show that Mec1 (hATR) promotes the association of Slx4 and Rtt107 with Dpb11 (hTopBP1) in response to MMS-induced DNA alkylation, suggesting that Slx4 and Rtt107 might coordinate repair factors specifically at damaged replication forks.

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Bibliographic Details
Published in:Molecular cell 2010-07, Vol.39 (2), p.162-164
Main Authors: Downey, Michael, Edenberg, Ellen R., Toczyski, David P.
Format: Article
Language:English
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Summary:In this issue of Molecular Cell, Ohouo et al. (2010) show that Mec1 (hATR) promotes the association of Slx4 and Rtt107 with Dpb11 (hTopBP1) in response to MMS-induced DNA alkylation, suggesting that Slx4 and Rtt107 might coordinate repair factors specifically at damaged replication forks.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2010.07.007