Immune infiltration in renal cell carcinoma

Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor‐infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further r...

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Bibliographic Details
Published in:Cancer science 2019-05, Vol.110 (5), p.1564-1572
Main Authors: Zhang, Shichao, Zhang, Erdong, Long, Jinhua, Hu, Zuquan, Peng, Jian, Liu, Lina, Tang, Fuzhou, Li, Long, Ouyang, Yan, Zeng, Zhu
Format: Article
Language:English
Subjects:
Algorithms
Antigens, CD - metabolism
Biomarkers
Carcinoma, Papillary - immunology
Carcinoma, Papillary - metabolism
Carcinoma, Papillary - pathology
Carcinoma, Renal Cell - immunology
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
CD8 antigen
CD8-Positive T-Lymphocytes - metabolism
Clear cell-type renal cell carcinoma
Clinical outcomes
Colorectal cancer
CTLA-4 Antigen - metabolism
CTLA-4 protein
Female
Gene expression
genomic alterations
Humans
Immune checkpoint
Immunomodulation
Immunoregulation
Immunotherapy
Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism
Kidney cancer
Kidney Neoplasms - immunology
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Liver cancer
Lymphocytes
Lymphocytes T
Lymphocytes, Tumor-Infiltrating - metabolism
Macrophages
Macrophages - metabolism
Male
Medical prognosis
Metastases
Methods
Mutation
Neoplasm Staging
Original
overall survival
Patients
Prognosis
Programmed Cell Death 1 Ligand 2 Protein - metabolism
renal cell carcinoma
Studies
Survival Analysis
T-Lymphocytes, Regulatory - metabolism
Therapeutic applications
Tumors
tumor‐infiltrating immune cells
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Summary:Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor‐infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further reveal the independent prognostic values of TIICs. CIBERSORT, an established algorithm, was applied to estimate the proportions of 22 immune cell types based on gene expression profiles of 891 tumors. Cox regression was used to evaluate the association of TIICs and immune checkpoint modulators with overall survival (OS). We found that CD8+ T cells were associated with prolonged OS (hazard ratio [HR] = 0.09, 95% confidence interval [CI].01‐.53; P = 0.03) in chromophobe carcinoma (KICH). A higher proportion of regulatory T cells was associated with a worse outcome (HR = 1.59, 95% CI 1.23‐.06; P 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.13996