Usefulness of the heparin-binding protein level to diagnose sepsis and septic shock according to Sepsis-3 compared with procalcitonin and C reactive protein: a prospective cohort study in China

ObjectivesOur aim was to assess the release level of heparin-binding protein (HBP) in sepsis and septic shock under the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).DesignProspective cohort study.SettingA general teaching hospital in China.ParticipantsAdult infect...

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Published in:BMJ open 2019-04, Vol.9 (4), p.e026527-e026527
Main Authors: Zhou, Yixuan, Liu, Zhen, Huang, Jun, Li, Guiling, Li, Fengying, Cheng, Yulan, Xie, Xinyou, Zhang, Jun
Format: Article
Language:English
Subjects:
Aged
Anticoagulants
Antimicrobial Cationic Peptides - blood
Bacterial infections
Biomarkers
Blood Proteins
C-Reactive Protein - analysis
China
Cohort analysis
Cohort Studies
Diagnostics
Female
Humans
Infections
Intensive care
Laboratories
Male
Medical diagnosis
Middle Aged
Neutrophils
Patients
Permeability
Procalcitonin - blood
Prospective Studies
Proteins
Sepsis
Sepsis - blood
Sepsis - diagnosis
Shock, Septic - blood
Shock, Septic - diagnosis
Software
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Summary:ObjectivesOur aim was to assess the release level of heparin-binding protein (HBP) in sepsis and septic shock under the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).DesignProspective cohort study.SettingA general teaching hospital in China.ParticipantsAdult infected patients with suspected sepsis and people who underwent physical examination were included. According to the health status and severity of illness, the research subjects were divided into healthy, local infection, sepsis non-shock and septic shock under Sepsis-3 definitions.Main outcome measuresPlasma levels of HBP, procalcitonin (PCT), C reactive protein (CRP) and complete blood count were detected in all subjects. Single-factor analysis of variance was used to compare the biomarker levels of multiple groups. A receiver operating characteristic (ROC) curve was used to assess the diagnostic capacity of each marker.ResultsHBP levels were significantly higher in patients with sepsis non-shock than in those with local infections (median 49.7ng/mL vs 11.8 ng/mL, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2018-026527