Prevalence of Antibody against Non‐A, non‐B Hepatitis Virus in Japanese Patients with Hepatocellular Carcinoma

Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus s...

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Bibliographic Details
Published in:Cancer science 1990-06, Vol.81 (6‐7), p.550-553
Main Authors: Ohkoshi, Showgo, Kojima, Hideo, Tawaraya, Hironobu, Miyajima, Tohru, Kamimura, Tomoteru, Asakura, Hitoshi, Satoh, Akira, Hirose, Shinichi, Hijikata, Makoto, Kato, Nobuyuki, Shimotohno, Kunitada
Format: Article
Language:English
Subjects:
Antibody
Blood transfusion
Blood transfusions
Carcinoma, Hepatocellular - immunology
Enzyme-linked immunosorbent assay
Female
Hepatitis
Hepatitis Antibodies - analysis
Hepatitis B
Hepatitis B surface antigen
hepatitis B virus
Hepatitis C
Hepatitis C - immunology
Hepatitis C virus
Hepatitis, Viral, Human - immunology
Hepatocellular carcinoma
Humans
Japan
Liver cancer
Liver Neoplasms - immunology
Male
Non‐A, non‐B hepatitis virus
Rapid Communication
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Summary:Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)‐negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg‐positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg‐negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody‐positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti‐HCV antibody and HBsAg‐negative hepatocellular carcinoma in Japan.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1990.tb02605.x