A blastema-predominant canine renal nephroblastoma with gingival metastasis: case report and literature review

Nephroblastomas are uncommon embryonal tumors in dogs. We report herein a blastema-predominant nephroblastoma with gingival metastasis in an 8-y-old Miniature Pinscher dog. Histologically, the mass was composed mainly of blastemal elements with minor epithelial and mesenchymal differentiation. Metas...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2018-05, Vol.30 (3), p.430-437
Main Authors: Chen, Bo, Li, Wen-Ta, Wang, Fun-In
Format: Article
Language:English
Subjects:
Animals
Brief Communications
case studies
Diagnosis, Differential
Dog Diseases - diagnosis
Dog Diseases - pathology
Dogs
epithelium
gingiva
Gingival Neoplasms - diagnosis
Gingival Neoplasms - secondary
Gingival Neoplasms - veterinary
humans
immunohistochemistry
Kidney Neoplasms - diagnosis
Kidney Neoplasms - pathology
Kidney Neoplasms - veterinary
Male
metastasis
Neoplasm Metastasis
Neoplasm Staging - veterinary
neoplasms
vimentin
Wilms Tumor - diagnosis
Wilms Tumor - secondary
Wilms Tumor - veterinary
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Summary:Nephroblastomas are uncommon embryonal tumors in dogs. We report herein a blastema-predominant nephroblastoma with gingival metastasis in an 8-y-old Miniature Pinscher dog. Histologically, the mass was composed mainly of blastemal elements with minor epithelial and mesenchymal differentiation. Metastatic masses in the gingiva had histologic and immunohistochemical features similar to those of the primary renal nephroblastoma. Neoplastic cells were extensively positive for both vimentin and PAX8, and scattered positive for cytokeratin. Using the clinical staging of human Wilms tumor, we staged our case as stage IV with
ISSN:1040-6387
1943-4936
1943-4936
DOI:10.1177/1040638718762560