Uterine carcinosarcoma (malignant mixed Müllerian tumor): case report in a goat and literature review

Carcinosarcomas are biphasic malignant tumors composed of 2 distinct neoplastic cell populations, epithelial cells and mesenchymal cells. A 13-y-old, female, mixed-breed goat was presented with a 1-wk history of anuria and lethargy. Transabdominal ultrasonography showed an irregular and heterogeneou...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2018-11, Vol.30 (6), p.955-961
Main Authors: Cossic, Brieuc, Hill, Jacqueline A., Cercone, Marta, Southard, Teresa
Format: Article
Language:English
Subjects:
Animals
Brief Communications
Diagnosis, Differential
Female
Goat Diseases - diagnosis
Goat Diseases - pathology
Goat Diseases - surgery
Goats
Immunohistochemistry - veterinary
Mixed Tumor, Mullerian - diagnosis
Mixed Tumor, Mullerian - pathology
Mixed Tumor, Mullerian - veterinary
Uterine Neoplasms - diagnosis
Uterine Neoplasms - pathology
Uterine Neoplasms - veterinary
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Summary:Carcinosarcomas are biphasic malignant tumors composed of 2 distinct neoplastic cell populations, epithelial cells and mesenchymal cells. A 13-y-old, female, mixed-breed goat was presented with a 1-wk history of anuria and lethargy. Transabdominal ultrasonography showed an irregular and heterogeneous structure in the region of the bladder and uterus and changes in the echogenicity of both kidneys. Given the poor prognosis, euthanasia was elected. Autopsy revealed a large mass within the uterine cervix and confirmed the changes in the urinary tract. Histopathology and immunohistochemistry revealed a mixed, anti-cytokeratin AE1/AE3–positive epithelial, and vimentin-positive mesenchymal neoplasm consistent with a homologous carcinosarcoma, also called malignant mixed Müllerian tumor, with areas of double-labeling. We highlight the complexity of the diagnosis of uterine neoplasms in domestic animals and in goats in particular.
ISSN:1040-6387
1943-4936
DOI:10.1177/1040638718808341