LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation

Our study aimed to investigate the role of long non-coding RNAs (lncRNA) TP73-AS1 in retinoblastoma (Rb). In the present study, we found that TP73-AS1 was up-regulated, while was down-regulated in Rb. TP73-AS1 and were inversely correlated in Rb tissues. In cells of Rb cell lines, overexpression of...

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Bibliographic Details
Published in:Bioscience reports 2019-05, Vol.39 (5)
Main Authors: Xia, Zhaoxia, Yang, Xiaoxi, Wu, Shuduan, Feng, Zhizhen, Qu, Lei, Chen, Xianghua, Liu, Linyu, Ma, Yanling
Format: Article
Language:English
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Summary:Our study aimed to investigate the role of long non-coding RNAs (lncRNA) TP73-AS1 in retinoblastoma (Rb). In the present study, we found that TP73-AS1 was up-regulated, while was down-regulated in Rb. TP73-AS1 and were inversely correlated in Rb tissues. In cells of Rb cell lines, overexpression of failed to affect TP73-AS1, while TP73-AS1 overexpression caused the down-regulated TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. overexpression played an opposite role and attenuated the effects of TP73-AS1 overexpression. Therefore, lncRNA TP73-AS1 may down-regulate to promote Rb cell proliferation.
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20190475