Fabrication of fillable microparticles and other complex 3D microstructures

Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2017-09, Vol.357 (6356), p.1138-1142
Main Authors: McHugh, Kevin J., Nguyen, Thanh D., Linehan, Allison R., Yang, David, Behrens, Adam M., Rose, Sviatlana, Tochka, Zachary L., Tzeng, Stephany Y., Norman, James J., Anselmo, Aaron C., Xu, Xian, Tomasic, Stephanie, Taylor, Matthew A., Lu, Jennifer, Guarecuco, Rohiverth, Langer, Robert, Jaklenec, Ana
Format: Article
Language:English
Subjects:
Additives
Biocompatibility
Biomedical materials
Chemical compounds
Drug delivery
Drug delivery systems
Drugs
Fabrication
Manufacturing
Materials Science
Microelectronics
Microfluidics
Microparticles
pH effects
pH sensors
Pharmacology
Printing
Side effects
Three dimensional printing
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Summary:Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aaf7447