Histopathologic features of melanocytic tumors in Xiphophorus melanoma receptor kinase (xmrk)-transgenic medaka (Oryzias latipes)

Melanocytic tumors in Xiphophorus melanoma receptor kinase (xmrk)-transgenic Carbio and HB11A strains of medaka were examined histopathologically at 7 months post-hatching. Medaka of both strains developed melanocytic tumors with a penetrance of 100%. In both strains, neoplastic cells containing int...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2019, Vol.32(2), pp.111-117
Main Authors: Sugiyama, Akihiko, Schartl, Manfred, Naruse, Kiyoshi
Format: Article
Language:English
Subjects:
anaplastic giant cell
Blood vessels
Giant cells
Growth patterns
Hatching
Kinases
Lesions
malignant melanoma
medaka
Melanin
Melanoma
Nuclei
Nuclei (cytology)
Pleomorphism
Short Communication
Skin cancer
Tumors
Xiphophorus
xmrk-transgenic
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Summary:Melanocytic tumors in Xiphophorus melanoma receptor kinase (xmrk)-transgenic Carbio and HB11A strains of medaka were examined histopathologically at 7 months post-hatching. Medaka of both strains developed melanocytic tumors with a penetrance of 100%. In both strains, neoplastic cells containing intracytoplasmic melanin pigment granules showed significant invasive growth patterns. In addition, epithelioid neoplastic cells were arranged in solid nests, and spindle neoplastic cells were arranged in interlacing streams and bundles. Nuclear atypia, anisokaryosis, cellular pleomorphism, and the appearance of anaplastic giant cells containing multiple nuclei or a single nucleus were observed in neoplastic lesions in both medaka strains. However, neither strain exhibited mitotic figures or invasion of blood vessels by neoplastic cells. Based on these histopathologic findings, the tumors were diagnosed as malignant melanoma. This is the first report of detailed histomorphologic characteristics of malignant melanoma in xmrk-transgenic medaka.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2018-0058