Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions

Chronic agonistic interactions promote the development of experimental psychopathologies in animals: a depression-like state in chronically defeated mice and the pathology of aggressive behavior in the mice with repeated wins. The abundant research data indicate that such psychopathological states a...

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Bibliographic Details
Published in:BioMed research international 2019-01, Vol.2019 (2019), p.1-13
Main Authors: Babenko, Vladimir N., Kovalenko, Irina L., Galyamina, Anna G., Smagin, Dmitry A., Kudryavtseva, Natalia N.
Format: Article
Language:English
Subjects:
Aggression - physiology
Aggressive behavior
Animals
Behavior
Behavior, Animal - physiology
Brain
Brain - metabolism
Brain - pathology
Brain - physiology
Brain research
Cell adhesion & migration
Collagen
Collagen - genetics
Depression - genetics
Depression - physiopathology
Disease
DNA methylation
Extracellular matrix
Extracellular Matrix - genetics
Gene expression
Gene Expression Regulation - genetics
Genes
Humans
Hypothalamus
Male
Mammals
Mice
Multigene Family - genetics
Neostriatum
Neurogenesis
Neurons
Neurosciences
Pathology
Peptides
Proteins
Psychological aspects
Psychology, Pathological
Psychopathology
Ribonucleic acid
RNA
RNA sequencing
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Summary:Chronic agonistic interactions promote the development of experimental psychopathologies in animals: a depression-like state in chronically defeated mice and the pathology of aggressive behavior in the mice with repeated wins. The abundant research data indicate that such psychopathological states are associated with significant molecular and cellular changes in the brain. This paper aims to study the influence of a 20-day period of agonistic interactions on the expression patterns of collagen family genes encoding the proteins which are basic components of extracellular matrix (ECM) in different brain regions of mice using the RNA-Seq database. Most of differentially expressed collagen genes were shown to be upregulated in the hypothalamus and striatum of chronically aggressive and defeated mice and in the hippocampus of defeated mice, whereas downregulation of collagen genes was demonstrated in the ventral tegmental areas in both experimental groups. Aberrant expression of collagen genes induced by chronic agonistic interactions may be indicative of specific ECM defects in the brain regions of mice with alternative social experience. This is the first study demonstrating remodeling of ECM under the development of experimental disorders.
ISSN:2314-6133
2314-6141
DOI:10.1155/2019/7276389