Oral Manifestation of Lymphomatoid Granulomatosis

• Published in: Head & neck pathology (Totowa, N.J.) N.J.), 2019-06, Vol.13 (2), p.270-276
• Main Authors: Pereira, Alessandro Antônio Costa, Ferreira, Christian Barros, Hanemann, João Adolfo Costa, Paranaiba, Livia Maris Ribeiro, Pereira, Patricia Peres Iucif, Rodrigues-Fernandes, Carla Isabelly, Sánchez-Romero, Celeste, de Almeida, Oslei Paes, Fonseca, Felipe Paiva
• Format: Article
• Language: English
• Subjects: Aged, 80 and over; Case Report; Dentistry; Female; Humans; Lymphomatoid Granulomatosis - diagnosis; Lymphomatoid Granulomatosis - pathology; Medicine; Medicine & Public Health; Mouth Neoplasms - diagnosis; Mouth Neoplasms - pathology; Oral and Maxillofacial Surgery; Otorhinolaryngology; Pathology
• ISSN: 1936-0568; 1936-055X; 1936-0568
• DOI: 10.1007/s12105-018-0910-x

Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein–Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult. The aim of this report is to present a rare case of LYG affecting an 86-year-old female patient that was diagnosed due to an extensive, ulcerated and painful oral lesion affecting the hard palate. Detailed microscopic evaluation together with a large immunohistochemical study were necessary to achieve the correct diagnosis of LYG.