The role of the triglyceride (triacylglycerol) glucose index in the development of cardiovascular events: a retrospective cohort analysis

This study aimed to evaluate the role of the triglyceride (triacylglycerol) glucose (TyG) index in predicting and mediating the development of cardiovascular disease (CVD). This cohort study included 6078 participants aged over 60 years who participated in a routine health check-up programme from 20...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.7320-7320, Article 7320
Main Authors: Li, Sangsang, Guo, Bingxin, Chen, Huanan, Shi, Zhan, Li, Yapeng, Tian, Qingfeng, Shi, Songhe
Format: Article
Language:English
Subjects:
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Aged
Blood Glucose - analysis
Body Mass Index
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cohort analysis
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Fasting
Fasting - blood
Feasibility Studies
Female
Follow-Up Studies
Glucose
Health risk assessment
Heart Rate
Humanities and Social Sciences
Humans
Incidence
Laboratory testing
Longitudinal Studies
Male
Middle Aged
multidisciplinary
Prevalence
Retrospective Studies
Risk Assessment - methods
Risk Factors
Science
Science (multidisciplinary)
Triglycerides - blood
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Summary:This study aimed to evaluate the role of the triglyceride (triacylglycerol) glucose (TyG) index in predicting and mediating the development of cardiovascular disease (CVD). This cohort study included 6078 participants aged over 60 years who participated in a routine health check-up programme from 2011 to 2017. The competing risk model, cox regression model and multimediator analyses were performed. TyG was calculated as ln [fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. During a median 6 years of follow-up, 705 (21.01/1000 person-years) CVD events occurred. In fully adjusted analyses, quartiles 3 and 4 versus quartile 1 of TyG index (adjusted subhazard ratios [SHRs] 1.33 [95% CI: 1.05–1.68] and 1.72 [1.37–2.16]) were associated with an increased risk of CVD events. The continuous time-dependent TyG remained significant in predicting CVD events (adjusted hazard ratios [HR] 1.43 [1.24–1.63]). The adverse estimated effects of body mass index (BMI) or resting heart rate (RHR) on CVD mediated through the joint effect of the baseline and follow-up TyG index. In addition, an effect mediated only through the follow-up TyG existed ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-43776-5