ssDNA viruses: key players in global virome

Single-stranded (ss)DNA viruses are extremely widespread, infect diverse hosts from all three domains of life and include important pathogens. Most ssDNA viruses possess small genomes that replicate by the rolling-circle-like mechanism initiated by a distinct virus-encoded endonuclease. High through...

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Bibliographic Details
Published in:Virusdisease 2019-03, Vol.30 (1), p.3-12
Main Authors: Malathi, V. G., Renuka Devi, P.
Format: Article
Language:English
Subjects:
Animals
Bacteria
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Birds
Cell Biology
DNA polymerase
DNA viruses
Endonuclease
Gene expression
Gene transfer
Genomes
Horizontal transfer
Life Sciences
Microbiology
Morphology
Protein Structure
Proteins
Review
Review Article
Single-stranded DNA
Taxonomy
Viruses
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Summary:Single-stranded (ss)DNA viruses are extremely widespread, infect diverse hosts from all three domains of life and include important pathogens. Most ssDNA viruses possess small genomes that replicate by the rolling-circle-like mechanism initiated by a distinct virus-encoded endonuclease. High throughput genome sequencing and improved bioinformatics tools have yielded vast information on presence of ssDNA viruses in diverse habitats. The simple genome of ssDNA viruses have high propensity to undergo mutation and recombination often emerging as threat to human civilization. Interestingly their genome is found embedded in fossils dating back to million years. The unusual evolutionary history of ssDNA viruses reveal evidences of horizontal gene transfer, sometimes between different species and genera.
ISSN:2347-3584
2347-3517
DOI:10.1007/s13337-019-00519-4