Early Lifestyle Interventions in People with Impaired Glucose Tolerance in Northern Colombia: The DEMOJUAN Project

Background: The objective of the demonstration project for type 2 diabetes prevention in the Barranquilla and Juan Mina (DEMOJUAN) study was to investigate the extent to which it is possible to reach normal glucose metabolism with early lifestyle interventions in people at high risk of type 2 diabet...

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Bibliographic Details
Published in:International journal of environmental research and public health 2019-04, Vol.16 (8), p.1403
Main Authors: Barengo, Noël C, Acosta, Tania, Arrieta, Astrid, Ricaurte, Carlos, Smits, Dins, Florez, Karen, Tuomilehto, Jaakko O
Format: Article
Language:English
Subjects:
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Disease control
Fasting
Glucose
Glucose tolerance
Health care
Health risks
Humid climates
Intervention
Lifestyles
Metabolism
Physical activity
Population
Prevention
Seminars
Studies
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Summary:Background: The objective of the demonstration project for type 2 diabetes prevention in the Barranquilla and Juan Mina (DEMOJUAN) study was to investigate the extent to which it is possible to reach normal glucose metabolism with early lifestyle interventions in people at high risk of type 2 diabetes (prediabetes), compared with those who receive standard usual care. Methods: DEMOJUAN was a randomized controlled trial conducted in Juan Mina and Barranquilla, Northern Colombia. Eligible participants were randomized into one of three groups (control group, initial nutritional intervention, and initial physical activity intervention). The duration of the intervention was 24 months. The main study outcome in the present analysis was reversion to normoglycemia. Relative risks and their corresponding 95% confidence intervals were calculated for reversal to normoglycemia and T2D incidence. Results: There was no statistically significant association between the intervention groups and reversion to normoglycemia. The relative risk of reversion to normoglycemia was 0.88 (95% CI 0.70–1.12) for the initial nutritional intervention group participants and 0.95 (95% CI 0.75–1.20) for the initial physical activity intervention group participants. Conclusions: Our study did not find any statistically significant differences in reversion to normoglycemia or the development of type 2 diabetes between the intervention groups and the control group in this population.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph16081403