Myosin 10 is involved in murine pigmentation

Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a...

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Bibliographic Details
Published in:Experimental dermatology 2019-04, Vol.28 (4), p.391-394
Main Authors: Liakath‐Ali, Kifayathullah, Vancollie, Valerie E., Sequeira, Inês, Lelliott, Christopher J., Watt, Fiona M.
Format: Article
Language:English
Subjects:
Alleles
Animals
Concise Communication
Epidermis
Female
Follicles
Gene Expression
Hair Color - genetics
Hair Follicle - pathology
hair follicles
Male
Melanocytes
Melanocytes - metabolism
Melanocytes - pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle contraction
Myosin
Myosins - genetics
Penetrance
Phenotypes
pigmentation
Pigmentation Disorders - genetics
Pigmentation Disorders - pathology
Skin
Skin pigmentation
Skin Pigmentation - genetics
Syndactyly
Syndactyly - genetics
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Summary:Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.13528