Calcium Buffering in the Heart in Health and Disease

Changes of intracellular Ca concentration regulate many aspects of cardiac myocyte function. About 99% of the cytoplasmic calcium in cardiac myocytes is bound to buffers, and their properties will therefore have a major influence on Ca signaling. This article considers the fundamental properties and...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2019-05, Vol.139 (20), p.2358-2371
Main Authors: Smith, Godfrey L, Eisner, David A
Format: Article
Language:English
Subjects:
Animals
Atrial Fibrillation - metabolism
Binding Sites
Buffers
Calcium Signaling - physiology
Calcium-Binding Proteins - metabolism
Calcium-Transporting ATPases - physiology
Cardiomyopathy, Hypertrophic - metabolism
Cytoplasm - metabolism
Heart Failure - metabolism
Humans
Hydrogen-Ion Concentration
Intracellular Fluid - metabolism
Ligands
Myocardial Contraction
Myocytes, Cardiac - metabolism
Sarcoplasmic Reticulum - enzymology
State of the Art
Troponin C - metabolism
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Summary:Changes of intracellular Ca concentration regulate many aspects of cardiac myocyte function. About 99% of the cytoplasmic calcium in cardiac myocytes is bound to buffers, and their properties will therefore have a major influence on Ca signaling. This article considers the fundamental properties and identities of the buffers and how to measure them. It reviews the effects of buffering on the systolic Ca transient and how this may change physiologically, and in heart failure and both atrial and ventricular arrhythmias, as well. It is concluded that the consequences of this strong buffering may be more significant than currently appreciated, and a fuller understanding is needed for proper understanding of cardiac calcium cycling and contractility.
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.118.039329