Calcium Buffering in the Heart in Health and Disease

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-05, Vol.139 (20), p.2358-2371
• Main Authors: Smith, Godfrey L, Eisner, David A
• Format: Article
• Language: English
• Subjects: Animals; Atrial Fibrillation - metabolism; Binding Sites; Buffers; Calcium Signaling - physiology; Calcium-Binding Proteins - metabolism; Calcium-Transporting ATPases - physiology; Cardiomyopathy, Hypertrophic - metabolism; Cytoplasm - metabolism; Heart Failure - metabolism; Humans; Hydrogen-Ion Concentration; Intracellular Fluid - metabolism; Ligands; Myocardial Contraction; Myocytes, Cardiac - metabolism; Sarcoplasmic Reticulum - enzymology; State of the Art; Troponin C - metabolism
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.118.039329

Changes of intracellular Ca concentration regulate many aspects of cardiac myocyte function. About 99% of the cytoplasmic calcium in cardiac myocytes is bound to buffers, and their properties will therefore have a major influence on Ca signaling. This article considers the fundamental properties and identities of the buffers and how to measure them. It reviews the effects of buffering on the systolic Ca transient and how this may change physiologically, and in heart failure and both atrial and ventricular arrhythmias, as well. It is concluded that the consequences of this strong buffering may be more significant than currently appreciated, and a fuller understanding is needed for proper understanding of cardiac calcium cycling and contractility.