A Hypothetical Model Concerning How Spike-Timing-Dependent Plasticity Contributes to Neural Circuit Formation and Initiation of the Critical Period in Barrel Cortex

• Published in: The Journal of neuroscience 2019-05, Vol.39 (20), p.3784-3791
• Main Authors: Kimura, Fumitaka, Itami, Chiaki
• Format: Article
• Language: English
• Subjects: Cortex (barrel); Critical period; Firing pattern; Hebbian plasticity; Insects; Interneurons; Long-term potentiation; Network formation; Neuroplasticity; Parvalbumin; Plastic properties; Plasticity; Presynaptic plasticity; Somatosensory cortex; Spikes; Synapses; Synaptic plasticity; Synaptic strength; Thalamus; Viewpoints; γ-Aminobutyric acid
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/jneurosci.1684-18.2019

Spike timing is an important factor in the modification of synaptic strength. Various forms of spike timing-dependent plasticity (STDP) occur in the brains of diverse species, from insects to humans. In unimodal STDP, only LTP or LTD occurs at the synapse, regardless of which neuron spikes first; the magnitude of potentiation or depression increases as the time between presynaptic and postsynaptic spikes decreases. This from of STDP may promote developmental strengthening or weakening of early projections. In bidirectional Hebbian STDP, the magnitude and the sign (potentiation or depression) of plasticity depend, respectively, on the timing and the order of presynaptic and postsynaptic spikes. In the rodent barrel cortex, multiple forms of STDP appear sequentially during development, and they contribute to network formation, retraction, or fine-scale functional reorganization. Hebbian STDP appears at L4-L2/3 synapses starting at postnatal day (P) 15; the synapses exhibit unimodal "all-LTP STDP" before that age. The appearance of Hebbian STDP at L4-L2/3 synapses coincides with the maturation of parvalbumin-containing GABA interneurons in L4, which contributes to the generation of L4-before-L2/3 spiking in response to thalamic input by producing fast feedforward suppression of both L4 and L2/3 cells. After P15, L4-L2/3 STDP mediates fine-scale circuit refinement, essential for the critical period in the barrel cortex. In this review, we first briefly describe the relevance of STDP to map plasticity in the barrel cortex, then look over roles of distinct forms of STDP during development. Finally, we propose a hypothesis that explains the transition from network formation to the initiation of the critical period in the barrel cortex.