Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

• Published in: Nutrients 2019-04, Vol.11 (4), p.761
• Main Authors: Papandreou, Christopher, Babio, Nancy, Díaz-López, Andrés, Martínez-González, Miguel Á, Becerra-Tomas, Nerea, Corella, Dolores, Schröder, Helmut, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M, Wärnberg, Julia, Martínez, Alfredo J, Serra-Majem, Lluís, Estruch, Ramon, Muñoz-Garach, Araceli, Lapetra, José, Pintó, Xavier, Tur, Josep A, Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, M Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Bulló, Mónica, Sorli, Jose V, Quifer, Mireia, Colom, Antoni, Oncina-Canovas, Alejandro, T Sierra, Lucas, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Sanchez-Villegas, Almudena, Casas, Rosa, F García, José C, Santos-Lozano, José M, Corbella, Emili, Del M Bibiloni, Maria, Diez-Espino, Javier, Asensio, Eva M, Torras, Laura, Morey, Marga, Compañ-Gabucio, Laura, S Lete, Itziar, Cenoz-Osinaga, Juan C, Castañer, Olga, Salas-Salvadó, Jordi
• Format: Article
• Language: English
• Subjects: Blood pressure; blood serum; Body mass index; Byproducts; Cardiovascular diseases; Communication; Creatinine; cross-sectional studies; Diabetes; elderly; Endocrinology; Epidemiology; Fasting; Geriatrics; Health care; Health risks; Health sciences; Hospitals; Internal medicine; leukocytes; Life expectancy; Medical research; Metabolic disorders; Metabolic syndrome; Nutrition research; obesity; Older people; Preventive medicine; Public health; Purines; regression analysis; Research centers; Sleep; Sleep apnea; Uric acid
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11040761

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndromein the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = 0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = 0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.