secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila

Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epith...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.7464, Article 7464
Main Authors: Feingold, Daniel, Knogler, Laura, Starc, Tanja, Drapeau, Pierre, O’Donnell, Michael J., Nilson, Laura A., Dent, Joseph A.
Format: Article
Language:English
Subjects:
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Animals
Chloride
Chloride Channels - chemistry
Chloride Channels - genetics
Chloride Channels - metabolism
Chloride conductance
Chlorides - metabolism
Dehydration
Diuretics
Drosophila melanogaster
Drosophila Proteins - metabolism
Epithelial cells
Epithelium - metabolism
Excretion
G protein-coupled receptors
Hormones
Humanities and Social Sciences
Insect Hormones - metabolism
Ion Channel Gating
Ion channels
Ion Transport
Malpighian Tubules - metabolism
Membrane permeability
multidisciplinary
Neurotransmission
Osmolarity
Osmoregulation
Permeability
Protein Domains
Science
Science (multidisciplinary)
Secretion
Water balance
Xenopus
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Summary:Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-42849-9