A vascular-task response dependency and its application in functional imaging of brain tumors

• Published in: Journal of neuroscience methods 2019-07, Vol.322, p.10-22
• Main Authors: Voss, Henning U., Peck, Kyung K., Petrovich Brennan, Nicole M., Pogosbekyan, Eduard L., Zakharova, Natalia E., Batalov, Artyom I., Pronin, Igor N., Potapov, Alexander A., Holodny, Andrei I.
• Format: Article
• Language: English
• Subjects: Brain tumors; Breath holding; fMRI; Neurosurgery; Vascular reactivity
• ISSN: 0165-0270; 1872-678X
• DOI: 10.1016/j.jneumeth.2019.04.004

[Display omitted] •We discovered a relationship between vascular (via breath-hold) and functional response in healthy subjects and subjects who underwent pre-surgical planning fMRI.•This “vaso-task dependency” can be utilized to estimate the effects of neurovascular uncoupling.•Neurovascular uncoupling can be overcome partially by using the vaso-task dependency to model vasoreactivity affected by brain tumors. Preoperative functional MRI (fMRI) is limited by a muted BOLD response caused by abnormal vasoreactivity and resultant neurovascular uncoupling adjacent to malignant brain tumors. We propose to overcome this limitation and more accurately identify eloquent areas adjacent to brain tumors by independently assessing vasoreactivity using breath-holding and incorporating these data into the fMRI analysis. Local vasoreactivity using a breath-holding paradigm with the same timing as the functional motor and language tasks was determined in 16 patients (9 glioblastomas, 1 anaplastic astrocytoma, 5 low grade astrocytomas, and 1 metastasis) and 6 healthy control subjects. We derived an fMRI model based on an observed vaso-task response dependency that takes into account the altered hemodynamics adjacent to brain tumors. In both healthy controls and brain tumor subjects, we found a statistical dependency between breath-hold and task BOLD response. In tumor subjects, activation maps that take into account this vaso-task dependency demonstrated clinically meaningful areas of activation that were not seen using the task-only analysis in about half of the cases studied. This included localization of language areas adjacent to brain tumors. The present preliminary results demonstrate that neurovascular uncoupling known to affect the accuracy of BOLD fMRI adjacent to brain tumors may be, at least partially, overcome by incorporating an observed vaso-task dependency in the BOLD signal analysis.