Transmission of tuberculosis and predictors of large clusters within three years in an urban setting in Tokyo, Japan: a population-based molecular epidemiological study

ObjectiveMolecular epidemiology is a promising tool for understanding tuberculosis transmission dynamics but has not been sufficiently utilised in Asian countries including Japan. The aim of this study was to estimate the proportion of TB cases attributable to recent transmission and to identify ris...

Full description

Saved in:
Bibliographic Details
Published in:BMJ open 2019-05, Vol.9 (5), p.e029295-e029295
Main Authors: Izumi, Kiyohiko, Murase, Yoshiro, Uchimura, Kazuhiro, Kaebeta, Aya, Ishihara, Keiko, Kaguraoka, Sumi, Takii, Takemasa, Ohkado, Akihiro
Format: Article
Language:English
Subjects:
Cities
Deoxyribonucleic acid
Diabetes
DNA
DNA fingerprints
Epidemiology
Genomes
Genotype & phenotype
Health surveillance
Homeless people
Infections
Infectious Diseases
Microscopy
Nurses
Observational studies
Patients
Population
Population-based studies
Public health
Questionnaires
Registration
Risk factors
Socioeconomic factors
Systematic review
Tuberculosis
Urban areas
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ObjectiveMolecular epidemiology is a promising tool for understanding tuberculosis transmission dynamics but has not been sufficiently utilised in Asian countries including Japan. The aim of this study was to estimate the proportion of TB cases attributable to recent transmission and to identify risk factors of genotype clustering and the development of large clusters within 3 years in an urban setting in Japan.Design and settingLong-term cross-sectional observational study combining the characteristics of patients with culture-positive TB notified in Shinjuku City, Tokyo (2002–2013), with genotype data of Mycobacterium tuberculosis. Primary outcome measureGenotype clustering rate and association between genotype clustering status and explanatory variables.ResultsAmong 1025 cases, 515 were localised within 113 genotype clusters. The overall clustering rate was 39.2%. Significantly higher rates were found in patients aged
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2019-029295