Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8

• Published in: Evidence-based complementary and alternative medicine 2019-01, Vol.2019 (2019), p.1-7
• Main Authors: Machado, Michel Mansur, Zuravski, Luísa, da Rosa, Emanoeli, Limberger, Jéssica Tamara, Chaves, Pamella Eduardha Espindola, Soares, Anelise Santos, Ribeiro, Juliana Gonçalves, Oliveira, Luís Flávio Souza de
• Format: Article
• Language: English
• Subjects: Accidental contamination; Analysis; Cancer; Cardiovascular disease; CD8 antigen; Cell culture; Chitin; Chromatin; Computer applications; Contamination; Cooperation; Depletion; Disease resistance; Drug dosages; Exoskeleton; Exoskeletons; Exposure; Genotoxicity; Immune response; Immunosuppression; Immunotherapy; Immunotoxicity; Infectious diseases; Interferon; Lymphocytes; Lymphocytes T; Medical research; Mutation; Statistical analysis; T cells; Toxicology; γ-Interferon
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2019/2815461

Fluazuron is one of the newest veterinary antitick medicines. Belonging to the benzoylphenylureas group, its mechanism of action acts by the interference of the formation of the chitin of the tick, which is responsible for the hardening of its exoskeletons. In addition to taking care of the health of the animal so that it receives the medication in the doses and the correct form, it is important to analyze the safety of the operator. Reduced resistance to infectious disease was a well-documented consequence of primary and acquired immunodeficiencies, but a novel finding following xenobiotic exposure. The awareness of the consequences of altered immune function is the most likely outcome of inadvertent exposure. The human health implications of studies in which chemical exposure reduced resistance to infection drove an early focus on immunosuppression within the toxicology community. The main objective is to perform the evaluation by computational platforms and in cell culture, searching for data that can serve as a foundation for a better understanding of the toxic effects involved with the accidental contamination of Fluazuron and, thus, to assist the medical community and users to understand the risks inherent in its use. As far as we can determine in the literature, our work has unmistakably demonstrated that the Fluazuron can cause genotoxicity by probable chromatin rearrangement and immunodepleting by specific reduction of the CD8 T lymphocyte subpopulation, mediated by the decrease in gamma interferon production. Although the use of Fluazuron is a necessity for tick control and for cattle management, we must bear in mind that the imminent risks to its application exist. Careless use can damage the immune system which in turn carries a gigantic hazard by opening a door to diseases and pathogens and leaving us defenseless.