Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: a cross-sectional study

• Published in: BMJ open 2019-05, Vol.9 (5), p.e030651-e030651
• Main Authors: Holm, Sverre, Oma, Ingvild, Hagve, Tor-Arne, Saatvedt, Kjell, Brosstad, Frank, Mikkelsen, Knut, Rydningen, Hans, Risnes, Ivar, Almdahl, Sven Martin, Ueland, Thor, Aukrust, Pål, Halvorsen, Bente, Hollan, Ivana
• Format: Article
• Language: English
• Subjects: Adult; Aged; Apolipoproteins; Atherosclerosis; Biopsy; Cardiovascular disease; Cardiovascular Medicine; Cholesterol; Cohort Studies; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary vessels; Cross-Sectional Studies; Cytokines; Epidemiology; Female; Health risk assessment; Heart attacks; Humans; Inflammation; Inflammation - blood; Inflammation - complications; Laboratories; Lipids; Lipoprotein(a) - blood; Lipoproteins; Male; Middle Aged; Patients; Rheumatic diseases; Rheumatic Diseases - blood; Rheumatic Diseases - complications; Rheumatoid arthritis; Risk Factors; Tumor necrosis factor-TNF
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2019-030651

ObjectivesPatients with various inflammatory rheumatic diseases (IRDs) have increased risk of atherothrombotic disease. Lipoprotein (a) (Lp(a)) is a risk factor for atherosclerosis but its role in IRD with accompanying coronary artery disease (CAD) is still unclear. We aimed to examine if serum Lp(a) levels differed between CAD patients with and without accompanying IRD.DesignA cross-sectional observational, patient-based cohort study.SettingReferred centre for coronary artery bypass grafting in the South Eastern part of Norway.Participants67 CAD patients with IRD (CAD/IRD) and 52 CAD patients without IRD (CAD/non-IRD). All patients were Caucasians, aged >18 years, without any clinically significant infection or malignancy.MethodsLp(a) levels in serum were analysed by particle enhanced immunoturbidimetric assay, and Lp(a) levels were related to clinical and biochemical characteristics of the patient population.ResultsWe found no differences in serum levels of Lp(a) between CAD patients with and without IRD. In general, we found that Lp(a) correlated poorly with clinical and biochemical parameters including C reactive protein with the same pattern in the CAD/non-IRD and CAD/IRD groups.ConclusionsOur data do not support a link between inflammation and Lp(a) levels in CAD and in general Lp(a) levels were not correlated with other risk factors for cardiovascular disease.