Novel electrode technologies for neural recordings

Neural recording electrode technologies have contributed considerably to neuroscience by enabling the extracellular detection of low-frequency local field potential oscillations and high-frequency action potentials of single units. Nevertheless, several long-standing limitations exist, including low...

Full description

Saved in:
Bibliographic Details
Published in:Nature reviews. Neuroscience 2019-06, Vol.20 (6), p.330-345
Main Authors: Hong, Guosong, Lieber, Charles M.
Format: Article
Language:English
Subjects:
631/1647/1453/2205
631/1647/1453/2208
631/1647/350
Action Potentials - physiology
Animal Genetics and Genomics
Animals
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain - cytology
Brain - physiology
Electrodes
Electrodes - trends
Electrodes, Implanted - trends
Electrophysiological recording
Equipment and supplies
Humans
Immune response
Innovations
Nervous system
Neural recording
Neurobiology
Neurons - physiology
Neurosciences
Oscillations
Review Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neural recording electrode technologies have contributed considerably to neuroscience by enabling the extracellular detection of low-frequency local field potential oscillations and high-frequency action potentials of single units. Nevertheless, several long-standing limitations exist, including low multiplexity, deleterious chronic immune responses and long-term recording instability. Driven by initiatives encouraging the generation of novel neurotechnologies and the maturation of technologies to fabricate high-density electronics, novel electrode technologies are emerging. Here, we provide an overview of recently developed neural recording electrode technologies with high spatial integration, long-term stability and multiple functionalities. We describe how these emergent neurotechnologies can approach the ultimate goal of illuminating chronic brain activity with minimal disruption of the neural environment, thereby providing unprecedented opportunities for neuroscience research in the future. Here, Hong and Lieber review recent developments in electrode technologies for the recording of single-unit spiking activity. They focus on advances in electrodes with high spatial integration, long-term stability and multifunctional capacities.
ISSN:1471-003X
1471-0048
1469-3178
DOI:10.1038/s41583-019-0140-6