Incidence, angiographic and clinical predictors, and impact of stent thrombosis: a 6-year survey of 6,545 consecutive patients

Objective We sought to determine the incidence, angiographic predictors, and impact of stent thrombosis (ST). Background Given the high mortality after ST, this study emphasises the importance of ongoing efforts to identify angiographic predictors of ST. Methods All consecutive patients with angiogr...

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Bibliographic Details
Published in:Netherlands heart journal 2019-06, Vol.27 (6), p.321-329
Main Authors: Rozemeijer, R., Wing Wong, C., Leenders, G., Timmers, L., Koudstaal, S., Rittersma, S. Z., Kraaijeveld, A., Bots, M., Doevendans, P., Stella, P., Voskuil, M.
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Angina pectoris
Angioplasty
Cardiology
Diabetes
Ejection fraction
Hypertension
Kappa coefficient
Medical Education
Medical imaging
Medicine
Medicine & Public Health
Mortality
Original
Original Article
Patients
Pharmacy
Software
Stents
Thrombosis
Vein & artery diseases
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Summary:Objective We sought to determine the incidence, angiographic predictors, and impact of stent thrombosis (ST). Background Given the high mortality after ST, this study emphasises the importance of ongoing efforts to identify angiographic predictors of ST. Methods All consecutive patients with angiographically confirmed ST between 2010 and 2016 were 1:4 matched for (1) percutaneous coronary intervention (PCI) indication and (2) index date ±6 weeks to randomly selected controls. Index PCI angiograms were reassessed by two independent cardiologists. A multivariable conditional logistic regression model was built to identify independent predictors of ST. Results Of 6,545 consecutive patients undergoing PCI, 55 patients [0.84%, 95% confidence interval (CI) 0.63–1.10%] presented with definite ST. Multivariable logistic regression identified dual antiplatelet therapy (DAPT) non-use as the strongest predictor of ST (odds ratio (OR) 10.9, 95% CI 2.47–48.5, p  
ISSN:1568-5888
1876-6250
DOI:10.1007/s12471-019-1253-2