The relationship between proton pump inhibitors and renal disease

ABSTRACT Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have foun...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian Journal of Nephrology 2018-07, Vol.40 (3), p.301-306
Main Authors: Morschel, Carine Franco, Mafra, Denise, Eduardo, José Carlos Carraro
Format: Article
Language:English
Subjects:
Acute Kidney Injury
Nephritis, Interstitial
Proton Pump Inhibitors
Renal Insufficiency, Chronic
Update
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD). The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function. Therefore, this review aimed to analyze recent studies on the matter and discuss the possible consequences of the long-term use of PPIs on renal function. RESUMO Os Inibidores da Bomba de Prótons (IBPs) são medicamentos que inibem a enzima H+/K+-ATPase no estômago, diminuindo a secreção gástrica. Esses medicamentos podem desencadear nefrite intersticial aguda, evento adverso potencialmente grave e que pode cursar com lesão renal aguda. Além disso, pesquisadores têm observado que o uso prolongado de IBPs pode também aumentar o risco de progressão da doença renal crônica (DRC). Com o crescimento da prescrição e o uso inadequado dessa classe de medicamentos, torna-se importante o estudo dos efeitos do uso prolongado dos IBPs sobre a função renal. Assim, esta revisão pretende abordar os recentes estudos sobre o tema e discutir as possíveis consequências que o uso contínuo dos inibidores da bomba de prótons pode causar na função renal.
ISSN:0101-2800
2175-8239
2175-8239
DOI:10.1590/2175-8239-jbn-2018-0021