Cervical vertebral body growth and emergence of sexual dimorphism: a developmental study using computed tomography

• Published in: Journal of anatomy 2019-06, Vol.234 (6), p.764-777
• Main Authors: Miller, Courtney A., Hwang, Seong Jae, Cotter, Meghan M., Vorperian, Houri K.
• Format: Article
• Language: English
• Subjects: Age; cervical vertebrae; Cervical Vertebral Maturation Index; Computed tomography; Developmental stages; Females; Gender differences; growth and development; Growth rate; human; Males; Morphometry; Original; Puberty; Sex differences; Sexual dimorphism; size and shape; Vertebrae; vertebral body
• ISSN: 0021-8782; 1469-7580
• DOI: 10.1111/joa.12976

The size and shape of human cervical vertebral bodies serve as a reference for measurement or treatment planning in multiple disciplines. It is therefore necessary to understand thoroughly the developmental changes in the cervical vertebrae in relation to the changing biomechanical demands on the neck during the first two decades of life. To delineate sex‐specific changes in human cervical vertebral bodies, 23 landmarks were placed in the midsagittal plane to define the boundaries of C2 to C7 in 123 (73 M; 50 F) computed tomography scans from individuals, ages 6 months to 19 years. Size was calculated as the geometric area, from which sex‐specific growth trend, rate, and type for each vertebral body were determined, as well as length measures of local deformation‐based morphometry vectors from the centroid to each landmark. Additionally, for each of the four pubertal‐staged age cohorts, sex‐specific vertebral body wireframes were superimposed using generalized Procrustes analysis to determine sex‐specific changes in form (size and shape) and shape alone. Our findings reveal that C2 was unique in achieving more of its adult size by 5 years, particularly in females. In contrast, C3–C7 had a second period of accelerated growth during puberty. The vertebrae of males and females were significantly different in size, particularly after puberty, when males had larger cervical vertebral bodies. Male growth outpaced female growth around age 10 years and persisted until around age 19–20 years, whereas females completed growth earlier, around age 17–18 years. The greatest shape differences between males and females occurred during puberty. Both sexes had similar growth in the superoinferior height, but males also displayed more growth in anteroposterior depth. Such prominent sex differences in size, shape, and form are likely the result of differences in growth rate and growth duration. Female vertebrae are thus not simply smaller versions of the male vertebrae. Additional research is needed to further quantify growth and help improve age‐ and sex‐specific guidance in clinical practice. This study analyzed wireframes of the cervical vertebral bodies in CT, birth to 20 years, in four cohorts of 5‐year increments. Major findings indicate C2 growth trend to be predominantly neural whereas C3–C7 follow the skeletal growth trend, sexual dimorphism in size and shape begins during puberty with males displaying more depth than females, and females reach maturity in shape ear