Species Distribution and Macrolide Susceptibility of Mycobacterium fortuitum Complex Clinical Isolates

The understanding of species distribution and inducible macrolide resistance in the complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were , followed by , , , and Most , , and isolates were inducibly resistant to clarithromycin, whereas two-thirds of the isolates were cl...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2019-06, Vol.63 (6)
Main Authors: Kim, Su-Young, Moon, Seong Mi, Jhun, Byung Woo, Kwon, O Jung, Huh, Hee Jae, Lee, Nam Yong, Lee, Seung Heon, Shin, Sung Jae, Kasperbauer, Shannon H, Huitt, Gwen A, Daley, Charles L, Koh, Won-Jung
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Clarithromycin
Clarithromycin - pharmacology
Drug Resistance, Bacterial
Mechanisms of Resistance
Microbial Sensitivity Tests
Mycobacterium fortuitum
Mycobacterium fortuitum - drug effects
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Summary:The understanding of species distribution and inducible macrolide resistance in the complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were , followed by , , , and Most , , and isolates were inducibly resistant to clarithromycin, whereas two-thirds of the isolates were clarithromycin susceptible. Clarithromycin-resistant isolates exhibited common mutations of (39), potentially involved in clarithromycin resistance.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02331-18