Summary and Trends of the Russian Gonococcal Antimicrobial Surveillance Programme, 2005 to 2016

• Published in: Journal of clinical microbiology 2019-06, Vol.57 (6)
• Main Authors: Kubanov, Alexey, Solomka, Viktoria, Plakhova, Xenia, Chestkov, Aleksandr, Petrova, Natalya, Shaskolskiy, Boris, Dementieva, Ekaterina, Leinsoo, Arvo, Gryadunov, Dmitry, Deryabin, Dmitry
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anti-Infective Agents - pharmacology; Child; Drug Resistance, Bacterial - drug effects; Epidemiology; Female; Gonorrhea - drug therapy; Gonorrhea - epidemiology; Gonorrhea - history; Gonorrhea - microbiology; History, 21st Century; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Neisseria gonorrhoeae - drug effects; Neisseria gonorrhoeae - genetics; Neisseria gonorrhoeae - isolation & purification; Population Surveillance; Russia - epidemiology; Young Adult
• ISSN: 0095-1137; 1098-660X; 1098-660X
• DOI: 10.1128/JCM.02024-18

The Russian Gonococcal Antimicrobial Surveillance Programme (RU-GASP) was established in 2004 and operated continuously during the years from 2005 to 2016. The aims of this study were to summarize the RU-GASP results over this 12-year period and evaluate the trends in antimicrobial resistance in Russia. In total, 5,038 verified isolates from 40 participating regions were tested for susceptibility to six antimicrobials via an agar dilution method. DNA loci involved in antimicrobial resistance were identified via minisequencing or DNA microarray techniques. From 2005 to 2016, increasing susceptibility to penicillin G (from 22.6% to 63.0%), tetracycline (from 34.8% to 53.0%), and ciprofloxacin (from 50.6% to 68.6%) was observed, but resistance to these drugs remained high. The proportions of isolates nonsusceptible to azithromycin and spectinomycin peaked in 2011 and decreased thereafter. Of the isolates, only 6 and 23 were identified as nonsusceptible to ceftriaxone according to the CLSI definitions and EUCAST breakpoint (0.57% of the total population), respectively. Comparison of antimicrobial resistance genetic determinants in 2005 versus those in 2016 showed a significant decrease in the number of isolates carrying chromosomal mutations. The proportion of isolates with wild-type genotypes increased from 11.7% in 2005 to 30.3% in 2016. Thus, the RU-GASP can be considered a successful gonorrhea surveillance program, and the current state of antimicrobial resistance in Russia is less serious than that in other WHO GASP regions.