Deciphering role of FGFR signalling pathway in pancreatic cancer

Recently, fibroblast growth factors are identified to play a vital role in the development and progression of human pancreatic cancer. FGF pathway is critical involved in numerous cellular processes through regulation of its downstream targets, including proliferation, apoptosis, migration, invasion...

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Bibliographic Details
Published in:Cell proliferation 2019-05, Vol.52 (3), p.e12605-n/a
Main Authors: Kang, Xiaodiao, Lin, Zeng, Xu, Minhui, Pan, Jun, Wang, Zhi‐wei
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Apoptosis
Cancer
Carcinogenesis
Carcinogens
Carrier Proteins - metabolism
Cell Line, Tumor
Cell Proliferation
FGF
FGFR
Fibroblast growth factor receptors
Fibroblast Growth Factors - metabolism
Growth factors
Humans
Metastases
Migration
Models, Biological
Organic chemistry
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - etiology
Pancreatic Neoplasms - metabolism
Receptors, Fibroblast Growth Factor - antagonists & inhibitors
Receptors, Fibroblast Growth Factor - metabolism
Review
Signal Transduction
Signaling
target
Therapeutic applications
therapy
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Summary:Recently, fibroblast growth factors are identified to play a vital role in the development and progression of human pancreatic cancer. FGF pathway is critical involved in numerous cellular processes through regulation of its downstream targets, including proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. In this review article, we describe recent advances of FGFR signalling pathway in pancreatic carcinogenesis and progression. Moreover, we highlight the available chemical inhibitors of FGFR pathway for potential treatment of pancreatic cancer. Furthermore, we discuss whether targeting FGFR pathway is a novel therapeutic strategy for pancreatic cancer clinical management.
ISSN:0960-7722
1365-2184
DOI:10.1111/cpr.12605