Impact of renal dysfunction on the choice of diagnostic imaging, treatment strategy, and outcomes in patients with stable angina

• Published in: Scientific reports 2019-05, Vol.9 (1), p.7882, Article 7882
• Main Authors: Kato, Takao, Uemura, Yukari, Naya, Masanao, Momose, Mitsuru, Matsumoto, Naoya, Suzuki, Eriko, Hida, Satoshi, Nakajima, Takatomo, Yamauchi, Takao, Tamaki, Nagara
• Format: Article
• Language: English
• Subjects: 692/308/409; 692/4019/2776; Aged; Angina; Angina, Stable - complications; Angina, Stable - diagnostic imaging; Angina, Stable - therapy; Angiography; Cardiovascular disease; Computed tomography; Computed Tomography Angiography; Congestive heart failure; Coronary Angiography; Coronary artery; Creatinine; Epidermal growth factor receptors; Female; Glomerular Filtration Rate; Hemodialysis; Humanities and Social Sciences; Humans; Male; Medical imaging; Middle Aged; multidisciplinary; Myocardial infarction; Prognosis; Renal function; Renal Insufficiency, Chronic - complications; Science; Science (multidisciplinary); Single photon emission computed tomography; Tomography; Tomography, Emission-Computed, Single-Photon; Trinucleotide repeats
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-44371-4

We investigated the interaction between the prognostic impact of a decrease in eGFR and the choice of initial diagnostic imaging modality for coronary artery disease. Out of 2878 patients who enrolled in the J-COMPASS study, 2780 patients underwent single photon emission computed tomography (SPECT), coronary computed tomography (CT) angiography, or coronary angiography (CAG) as an initial diagnostic test. After excluding patients with routine hemodialysis or lacked serum creatinine levels, 2096 patients in the non-decreased eGFR group (eGFR ≥ 60 ml/min/1.73 m 2 ) and 557 patients in the decreased eGFR group (eGFR