Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection

• Published in: Journal of general virology 2019-01, Vol.100 (1), p.26-34
• Main Authors: Pan, Diganta, Das, Arpita, Srivastav, Sudesh K, Traina-Dorge, Vicki, Didier, Peter J, Pahar, Bapi
• Format: Article
• Language: English
• Subjects: Animals; B-Lymphocytes - immunology; CD58 Antigens - biosynthesis; Gene Expression; Interleukin-2 - metabolism; Intestinal Mucosa - pathology; Intraepithelial Lymphocytes - immunology; Lymphocyte Activation; Macaca; Plasma - virology; Short Communication; Simian Acquired Immunodeficiency Syndrome - pathology; Simian Immunodeficiency Virus - isolation & purification; Tumor Necrosis Factor-alpha - metabolism; Viral Load
• ISSN: 0022-1317; 1465-2099
• DOI: 10.1099/jgv.0.001181

For an effective T-cell activation and response, co-stimulation is required in addition to the antigen-specific signal from their antigen receptors. The CD2/CD58 interaction is considered as one of the most important T-cell co-stimulatory pathways for T-cell activation and proliferation, and its role in regulating intestinal T-cell function in acute and chronic SIV -infected macaques is poorly documented. Here, we demonstrated a significant reduction of CD58 expression in both T- and B-cell populations during acute SIV infection along with high plasma viral load and a loss of intestinal CD4 T cells compared to SIV-uninfected control macaques. The reduction of CD58 expression in T cells was correlated with the reduced expression of T-cell-mediated IL-2 and TNFα production. Together, these results indicate that reduction in the CD2/CD58 interaction pathway in mucosal lymphocytes might play a crucial role in mucosal T-cell dysfunction during acute SIV/HIV infection.