Self-Assembled Benznidazole-Loaded Cationic Nanoparticles Containing Cholesterol/Sialic Acid: Physicochemical Properties, In Vitro Drug Release and In Vitro Anticancer Efficacy

Cationic polymeric nanoparticles (NPs) have the ability to overcome biological membranes, leading to improved efficacy of anticancer drugs. The modulation of the particle-cell interaction is desired to control this effect and avoid toxicity to normal cells. In this study, we explored the surface fun...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-05, Vol.20 (9), p.2350
Main Authors: Dos Santos-Silva, Alaine Maria, de Caland, Lilia Basílio, do Nascimento, Ednaldo Gomes, Oliveira, Ana Luiza C de S L, de Araújo-Júnior, Raimundo F, Cornélio, Alianda Maira, Fernandes-Pedrosa, Matheus F, da Silva-Júnior, Arnóbio Antônio
Format: Article
Language:English
Subjects:
Benznidazole
Cancer therapies
Cations
Cholesterol
Colorectal cancer
Cytotoxicity
Disruption
Drug delivery systems
Drug development
Efficiency
Nanoparticles
Oxidative stress
Particle size
Physicochemical properties
Self-assembly
Studies
Surface properties
Therapeutic targets
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Summary:Cationic polymeric nanoparticles (NPs) have the ability to overcome biological membranes, leading to improved efficacy of anticancer drugs. The modulation of the particle-cell interaction is desired to control this effect and avoid toxicity to normal cells. In this study, we explored the surface functionalization of cationic polymethylmethacrylate (PMMA) NPs with two natural compounds, sialic acid (SA) and cholesterol (Chol). The performance of benznidazole (BNZ) was assessed in vitro in the normal renal cell line (HEK-293) and three human cancer cell lines, as follows: human colorectal cancer (HT-29), human cervical carcinoma (HeLa), and human hepatocyte carcinoma (HepG2). The structural properties and feasibility of NPs were evaluated and the changes induced by SA and Chol were determined by using multiple analytical approaches. Small (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20092350