MicroRNA Involvement in Allergic and Non-Allergic Mast Cell Activation

• Published in: International journal of molecular sciences 2019-04, Vol.20 (9), p.2145
• Main Authors: Shefler, Irit, Salamon, Pazit, Mekori, Yoseph A
• Format: Article
• Language: English
• Subjects: Actin; Antigens; Apoptosis; Calcium influx; Calcium ions; Cell activation; Cell cycle; Chemokines; Cytokines; Degranulation; Enzymes; Genes; Growth factors; Immune response; Immune system; Immunoglobulin E; Kinases; MAP kinase; MicroRNAs; miRNA; NF-κB protein; Peptides; Phosphorylation; Polymerization; Protein expression; Protein kinase C; Protein-tyrosine kinase; Proteins; Review; RNA polymerase; siRNA; Spleen; Syk protein; Transfection; Tumor necrosis factor-TNF; Tyrosine
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20092145

Allergic inflammation is accompanied by the coordinated expression of numerous genes and proteins that initiate, sustain, and propagate immune responses and tissue remodeling. MicroRNAs (miRNAs) are a large class of small regulatory molecules that are able to control the translation of target mRNAs and consequently regulate various biological processes at the posttranscriptional level. MiRNA profiles have been identified in multiple allergic inflammatory diseases and in the tumor microenvironment. Mast cells have been found to co-localize within the above conditions. More specifically, in addition to being essential in initiating the allergic response, mast cells play a key role in both innate and adaptive immunity as well as in modulating tumor growth. This review summarizes the possible role of various miRNAs in the above-mentioned processes wherein mast cells have been found to be involved. Understanding the role of miRNAs in mast cell activation and function may serve as an important tool in developing diagnostic as well as therapeutic approaches in mast cell-dependent pathological conditions.