Association of ACTN3 Polymorphism with Body Somatotype and Cardiorespiratory Fitness in Young Healthy Adults

encodes the protein α-actinin-3, which affects the muscle phenotype. In the present study, we examined the association of R577X polymorphism with body somatotype and cardiorespiratory fitness in young, healthy adults. The study group included 304 young adults, in whom cardiorespiratory fitness was e...

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Bibliographic Details
Published in:International journal of environmental research and public health 2019-04, Vol.16 (9), p.1489
Main Authors: Potocka, Natalia, Penar-Zadarko, Beata, Skrzypa, Marzena, Braun, Marcin, Zadarko-Domaradzka, Maria, Ozimek, Mariusz, Nizioł-Babiarz, Edyta, Barabasz, Zbigniew, Zawlik, Izabela, Zadarko, Emilian
Format: Article
Language:English
Subjects:
Actinin - genetics
Adults
Body Composition
Body fat
Body height
Body water
Body weight
Cardiorespiratory Fitness
Cross-Sectional Studies
Deoxyribonucleic acid
DNA
Electrophoresis
Endurance
Female
Gene expression
Gene polymorphism
Genotype
Genotype & phenotype
Heart rate
Humans
Male
Morphology
Nutrition
Oxygen Consumption
Physical activity
Physical fitness
Polymerase chain reaction
Polymorphism
Polymorphism, Genetic
Proteins
Restriction fragment length polymorphism
Smoking
Somatotypes
Young Adult
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Summary:encodes the protein α-actinin-3, which affects the muscle phenotype. In the present study, we examined the association of R577X polymorphism with body somatotype and cardiorespiratory fitness in young, healthy adults. The study group included 304 young adults, in whom cardiorespiratory fitness was evaluated and the maximum oxygen uptake was determined directly. The somatotype components were calculated according to the Heath-Carter method. Genotyping for the gene was performed using a polymerase chain reaction followed by high-resolution melting analysis. In the female group, a lower maximal heart rate (HRmax) was more strongly associated with the RR genotype ( = 0.0216) than with the RX and XX genotypes. In the male group, the RX genotype, as compared with other genotypes, tended to be associated with a lower percentage of adipose tissue ( = 0.0683), as also reflected by the body mass index ( = 0.0816). gene polymorphism may affect cardiorespiratory fitness. Our analysis of gene polymorphism does not clearly illustrate the relationships among genotype, body composition, and somatotype in young, healthy adults.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph16091489