Compromised global embryonic transcriptome associated with advanced maternal age

Purpose To investigate the global transcriptome and associated embryonic molecular networks impacted with advanced maternal age (AMA). Methods Blastocysts derived from donor oocyte IVF cycles with no male factor infertility (

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2019-05, Vol.36 (5), p.915-924
Main Authors: McCallie, Blair R., Parks, Jason C., Trahan, G. Devon, Jones, Kenneth L., Coate, Breanne D., Griffin, Darren K., Schoolcraft, William B., Katz-Jaffe, Mandy G.
Format: Article
Language:English
Subjects:
Adult
Age
Bioinformatics
Blastocyst - metabolism
Blastocysts
Embryo Biology
Embryo Implantation
Embryogenesis
Embryonic Development
Embryos
ESR1 protein
Female
Fertilization in Vitro
Fetuses
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Gynecology
Human Genetics
Humans
Infertility
Infertility, Female - genetics
Infertility, Male - genetics
Male
Maternal Age
Medicine
Medicine & Public Health
Pattern formation
Reproductive Medicine
Ribonucleic acid
RNA
Signal transduction
Sp1 protein
Transcription
Transcriptome
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Description
Summary:Purpose To investigate the global transcriptome and associated embryonic molecular networks impacted with advanced maternal age (AMA). Methods Blastocysts derived from donor oocyte IVF cycles with no male factor infertility (
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-019-01438-5