Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia

Secretoglobins (SCGBs) are cytokine-like small molecular weight secreted proteins with largely unknown biological functions. Three SCGB proteins, SCGB1A1, SCGB3A1, and SCGB3A2, are predominantly expressed in lung airways. To gain insight into the possible functional relationships among the SCGBs, th...

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Published in:The journal of histochemistry and cytochemistry 2019-06, Vol.67 (6), p.453-463
Main Authors: Naizhen, Xu, Kido, Taketomo, Yokoyama, Shigetoshi, Linnoila, R. Ilona, Kimura, Shioko
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Epithelium - metabolism
Gene Expression Regulation
Lung - cytology
Mice
Proteins - genetics
Secretoglobins - genetics
Spatio-Temporal Analysis
Uteroglobin - genetics
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Summary:Secretoglobins (SCGBs) are cytokine-like small molecular weight secreted proteins with largely unknown biological functions. Three SCGB proteins, SCGB1A1, SCGB3A1, and SCGB3A2, are predominantly expressed in lung airways. To gain insight into the possible functional relationships among the SCGBs, their protein and mRNA expression patterns were examined in lungs during gestation and in adult mice, using Scgb3a1-null and Scgb3a2-null mice as negative controls, by immunohistochemistry and by qRT-PCR analysis, respectively. The three SCGBs exhibited unique spatiotemporal expression patterns during embryogenesis. The lack of Scgb3a1 or Scgb3a2 did not affect expression of the other Scgb genes as determined by mRNA measurements. Moreover, the lack of Scgb3a1 or Scgb3a2 did not affect development of the pulmonary neuroepithelial bodies during embryogenesis, while the lack of Scgb3a2 may have resulted in slightly fewer ciliated cells than in the wild-type. These results suggest that SCGB1A1, SCGB3A1, and SCGB3A2 each may possess its own unique biological function.
ISSN:0022-1554
1551-5044
DOI:10.1369/0022155419829050